ABSTRACT
Este estudo teve por objetivo avaliar os efeitos da nutrição parenteral total ou enteral, associadas ou não à glutamina, sobre a motilidade gastrintestinal em equinos submetidos à inanição e realimentação. Foram utilizados 16 equinos adultos hígidos, sem raça definida, de ambos os sexos, quatro machos e 12 fêmeas, com idade variando entre quatro e 14 anos e peso corporal médio de 248,40 + 2,28 kg, divididos em quatro grupos, quatro animais por grupo: Grupo I (ENTGL): fluidoterapia enteral com eletrólitos associada a glutamina; Grupo II (PARGL): Nutrição parenteral total (NPT) associada a glutamina; Grupo III (ENTFL): fluidoterapia enteral com eletrólitos; Grupo IV (PARFL): fluidoterapia parenteral. O delineamento experimental foi inteiramente ao acaso, em um esquema fatorial 4x12 (grupos x tempo de colheita), para cada fase, e suas médias comparadas pelo teste de Duncan ao nível de 5% de significância. Independente do grupo experimental ocorreu redução da motilidade gastrintestinal durante a fase de inanição, mais pronunciada nos grupos PARGL e PARFL. Uma vez restabelecida a alimentação a motilidade gastrintestinal retornou à normalidade.
This study aimed to evaluate the effects of enteral or total parenteral nutrition, associated or not with glutamine, on gastrointestinal motility in horses subjected to starvation and refeeding. 16 healthy, mixed-breed adult horses of both sexes, four geldings and 12 mares, with ages ranging from four to 14 years and an average body weight of 248.40 + 2.28 kg, were divided into four groups, four animals per group: Group I (ENTGL): enteral fluid therapy with electrolytes associated with glutamine; Group II (PARGL): total parenteral nutrition (TPN) associated with glutamine; Group III (ENTFL): enteral fluid therapy with electrolytes; Group IV (PARFL): parenteral fluid therapy. The experimental design was entirely randomized, in a 4x12 factorial scheme (groups x harvest time), for each phase, and their means compared by the Duncan test at the level of 5% significance. Regardless of the experimental group, there was a reduction in gastrointestinal motility during the starvation phase, which was more pronounced in the PARGL and PARFL groups. Once the food was restored, gastrointestinal motility returned to normal.
Subject(s)
Animals , Enteral Nutrition/veterinary , Parenteral Nutrition, Total/veterinary , Gastrointestinal Motility , Horses , Starvation/veterinary , Glutamine/therapeutic useABSTRACT
Starvation changes the pituitary hormones serum levels, especially gonadotropins and growth hormone [GH]. There are controversies about the effects of starvation on the hormonal changes of the two axes. Therefore, this study was carried out to show the interaction of hypothalamus-pituitary-gonad [HPG] and GH axes during fasting. In this experimental study, thirty-two adult male rats were divided into four equal groups. The starvation group was deprived of food for 4 days with free access to water and received injection of the vehicle [corn oil, 1 ml/day]. The control group had free access to water and st and ard laboratory animal food and received injection of the vehicle [corn oil, 1 ml/day]. Starvation + testosterone [St+T] group were deprived of food for 4 days with free access to water and received injection of testosterone [1 mg/kg/day]. Starvation + estradiol [St+E] group was deprived of food for 4 days with free access to water and received injection of estradiol [1 mg/kg /day]. Then the levels of FSH, LH, GH, estradiol and testosterone were measured. Data were analyzed using ANOVA and Toki tests. During the fasting, the level of serum GH increased to 64% but the level of FSH, LH and testosterone decreased by 33%, 31% and 41%, respectively [p<0.001]. No significant change was found in serum level of estradiol. The increase of serum GH levels in St+T and St+E groups were less than that of the starvation group [p<0.001]. Also in St+T and St+E groups the decrease of FSH and LH were more than those in the starvation group [p<0.001]. Based on the results of this study, the two axes showed the same mechanism in response to short-term starvation